Is timing everything? A Bayesian meta-analysis of the prognostic and diagnostic utility of bloodculture time-to-positivity (TTP) and differential time-to positivity (DTP) for bloodstream infections

Zaghi I, Sambri V, Lewis RE. 32nd European Congress of Clinical Microbiology and Infectious Diseases, Lisbon, Portugal. Abstract

Managing drug interactions with targeted chemotherapy

Brüggemann R et al. Lancet Haematol 2022;9:e58–e72.

This article provides a state of the art review on pharmacokinetic drug-drug interactions of antifungal therapy with target chemotherapy agents used in the treatment of haematologic malignancies

Early low-dose CT plus pulmonary angiography to improve the diagnosis of aspergillosis

Stanzani M et al. J Infect 2021; 83:371–380.

Mould pneumonia is a common complication of chemotherapy for hematological malignancies. Low-dose chest computed tomography (CT) detected abnormalities in 63% of patients within 48h of fever. One-quarter of infiltrates were amenable to CT pulmonary angiography (CTPA) to assess the vessel occlusion sign (VOS).The VOS exhibited a high sensitivity and specificity for mould pneumonia.

Chimeric antigen receptor T-cell therapy for the treatment of lymphoid malignancies-is there an excess risk for infection?

Gudiol C, Lewis RE, Strati P, Kontoyiannis DP. Lancet Haematol 2021; 8:e216–e228.